Anti-IgA Antibody
Introduction
Low serum
concentrations of IgA can be the result of lack of production of IgA by
the liver or increased destruction of circulating IgA of by antibodies
directed toward IgA. It is important to distinguish between these two
causes of hypogammaglobulemic IgA because the presence of anti-IgA puts an
individual at risk for an anaphylactic reaction if one receives
intravenous immunoglobulin.
Indication for
Testing
All individuals who are hypogammaglobulinemic for IgA
should be tested for anti-IgA.
Detection Method
Anti-IgA
antibodies are detected by standard immunoradiometric (IRMA) assay for the
IgG isotype to IgA.
Interpretation of Test
Results
| Negative: |
< 150% of Negative Control |
| Limited specificity or low titer class specific
antibodies: |
151 to 200% of Negative Control |
| Class specific or high titer limited specificity
antibodies: |
> 200% of Negative Control |
Specimen Collection and Shipping
Requirements
- Collect one (1) 10 ml red or tiger top ube.
- Ship at room temperature in prepaid FedEx mailers overnight, next
day morning
Turn around Time
Processing
of specimens begins immediately upon receipt at our facilities. Results
are routinely available within 10 business days and are faxed to the requesting physician.
Cost
Included in our fees
are specimen collection and shipping materials, all courier and shipping
charges, telephone and written reports.
Please call 1-877-737-7652 for pricing information.
Contact Details:
References
Mochizuki S, Smith CI,
Hallgren R, Hammarstrom L. Systemic immunization against IgA in
immunoglobulin deficiency. Clin Exp Immunol 1993;94:334-36.
Ferreira A, Garcia Rodriquez MC, Lopez-Trascasa M, Pasual Salcedo D,
Fontan G. Anti-IgA antibodies in selective IgA deficiency and in primary
immunodeficient patients treated with gammaglobulin. Clin Immunol
Immunolpathol 1988;47:199-207.
Sandler SG, Mallory D, Malamut D, Eckrick R. IgA anaphylactic
transfusion reactions. Transfus Med Rev 1995;9:1-8.
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