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Anti-IgA Antibody

• Introduction
• Indication for Testing
• Detection Method
• Interpretation of Test Results
• Specimen Collection and Shipping Requirements
• Turn around Time
• Cost
• Request Hard Copy
• References

Introduction
Low serum concentrations of IgA can be the result of lack of production of IgA by the liver or increased destruction of circulating IgA of by antibodies directed toward IgA. It is important to distinguish between these two causes of hypogammaglobulemic IgA because the presence of anti-IgA puts an individual at risk for an anaphylactic reaction if one receives intravenous immunoglobulin.

Indication for Testing
All individuals who are hypogammaglobulinemic for IgA should be tested for anti-IgA.

Detection Method
Anti-IgA antibodies are detected by standard immunoradiometric (IRMA) assay for the IgG isotype to IgA.

Interpretation of Test Results

Negative:	< 150% of Negative Control
Limited specificity or low titer class specific antibodies:	151 to 200% of Negative Control
Class specific or high titer limited specificity antibodies:	200 of Negative Control

Specimen Collection and Shipping Requirements

• Collect one (1) 10 ml red or tiger top ube.
• Ship at room temperature in prepaid FedEx mailers overnight, next day morning

Turn around Time
Processing of specimens begins immediately upon receipt at our facilities. Results are routinely available within 7 to 10 days and are initially faxed, then mailed to the requesting physician.

Cost
Included in our fees are specimen collection and shipping materials, all courier and shipping charges, telephone and written reports, and consultation with physicians. Please call (312) 274-1928 for pricing information.

Request Hard Copy

Ferreira A, Garcia Rodriquez MC, Lopez-Trascasa M, Pasual Salcedo D, Fontan G. Anti-IgA antibodies in selective IgA deficiency and in primary immunodeficient patients treated with gammaglobulin. Clin Immunol Immunolpathol 1988;47:199-207.

Sandler SG, Mallory D, Malamut D, Eckrick R. IgA anaphylactic transfusion reactions. Transfus Med Rev 1995;9:1-8.