Soluble CD23
Introduction
Soluble CD23
is a 25 kDa fragment produced by the proteolytic cleavage of the
transmembrane glycoprotein CD23. IL4 released by TH2 cell binds to its
receptor on B cells with the release of soluble CD23 into the serum. Thus
elevation of serum soluble CD23 concentrations reflects activation of B
cells. Polyclonal activation of B cells has been demonstrated among
patients with endometriosis. In fact, serum soluble CD23 concentrations
are significantly elevated among patients with endometriosis compared with
controls (p < 0.0001).
Indications for
Testing
Infertile women whose symptoms are suggestive of
endometriosis could be investigated with soluble CD23.
Detection Method
Soluble
CD23 is detected by standard ELISA procedure.
Interpretation of Test
Results
Normal range is 15-73 u/ml.
Specimen Collection and Shipping
Requirements
- Collect one (1) 10 ml red or tiger top tube.
- Ship at room temperature in prepaid FedEx mailers overnight, next
day morning.
Turn around Time
Processing
of specimens begins immediately upon receipt at our facilities. Results
are routinely available within 7 to 10 days and are initially faxed, then
mailed to the requesting physician.
Cost
Included in our fees
are specimen collection and shipping materials, all courier and shipping
charges, telephone and written reports, and consultation with physicians.
Please call (312) 274-1928 for pricing information.
Request Hard Copy
References
Dmowski WP, Rana
N, Michalowska J, Friberg J, Papierniak C, El-Roiey A. The effect of
endometriosis, its stage, activity, and of autoantibodies on in vitro
Fertilization and embryo transfer success rates. Fertil Steril
1995;63:535-562.
Odukoya OA BansaalA Wilson AP, Weetman AP, Cooke ID. Serum soluble CD23
in patients with endometriosis and the effect of treatment with danazol
and leuprolide acetate depot injection. Hum Reprod 1995;10:942-946.
Gordon J. CD23 and B cell activation. Clin Exp Allergy
1992;22:199-204.
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