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Endometriosis Panel
Summary
Endometriosis is a
common gynecologic disease frequently associated with infertility. There
is increasing evidence that immunologic mechanisms play a role in the
pathogenesis and pathophysiology of endometriosis. The immunologic
alterations in patients with endometriosis are associated with an
exaggerated B-cell response, which can be measured as elevated serum
levels of autoantibodies and soluble CD23. CA125 has also been used as a
marker of endometriosis.
Panel Tests Included
Anti-phospholipid antibodies
(APA) and anti-nuclear
antibodies (ANA) as well as CA125 and soluble CD23 are used as
markers to predict the presence of endometriosis. The following
sensitivities, specificity, positive, and negative predictive values were
found:
| Test |
Sensitivity |
Specificity
(+) |
Predictive
(-) |
Predictive |
| CA125 alone |
93% |
54% |
56% |
93% |
| sCD23 alone |
90% |
45% |
36% |
93% |
| CA125 and sCD 23 |
90% |
63% |
72% |
86% |
CA125, sCD 23,
APA and ANA |
90% |
67% |
76% |
86% |
Specimen Collection and Shipping
Requirements
- Collect two (2) 10 ml red or tiger top tubes.
- Ship at room temperature in prepaid FedEx mailers overnight, next
day morning.
Turn Around Time
Processing of specimens
begins immediately upon receipt at our facilities. Results are routinely
available within 7 to 10 days and are initially faxed, then mailed to the
requesting physician.
Cost
Included in our fees are specimen
collection and shipping materials, all courier and shipping charges,
telephone and written reports, and consultation with physicians. Please
call (312) 274-1928 for pricing information.
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