Immunoglobulin Panel (IgG, IgM, IgA)
Introduction
Patients with
autoimmune diseases characteristically exhibit significant abnormalities
in total immunoglobulin isotypes. A very high incidence of such
gammopathies is also seen in women experiencing endometriosis, recurrent
pregnancy loss, infertility and failure of implantation after in vitro
fertilization. The occurrence of hypergammaglobulinemias has been reported
to decrease the clinical pregnancy rate with IVF. Hypogammaglobulinemia of
IgA needs to be further evaluated to rule out IgA antibodies before
treatment with intravenous immunoglobulin is considered.
Indications for
Testing
All women experiencing recurrent pregnancy loss,
undergoing in vitro fertilization procedures or having symptoms of
autoimmune disease should be tested for the presence of gammopathies. An
immunoglobulin panel should be performed on all individuals prior to
receiving intravenous immunoglobulin therapy to rule out
hypogammaglobulinemic serum concentrations of IgA.
Detection Method
Total
immunoglobulin G, M, and A levels are determined by standard nephelometric
technique.
Interpretation of Test
Results
Normal serum concentrations for immunoglobulins A, G and
M are as follows:
| IgA |
82 - 453 mg/dl |
| IgG |
751 - 1560 mg/dl |
| IgM |
46 - 304 mg/dl |
Any IgA concentration less that 68mg/dl should be followed up with and
anti-IgA assay.
Specimen Collection and Shipping
Requirements
- Collect one (1) 10 ml red or tiger top tube.
- Ship at room temperature in prepaid FedEx mailers overnight, next
day morning.
Turn around Time
Processing
of specimens begins immediately upon receipt at our facilities. Results
are routinely available within 10 business days and are faxed to the
requesting physician.
Cost
Included in our fees
are specimen collection and shipping materials, all courier and shipping
charges, telephone and written reports.
Please call 1-877-737-7652 for pricing information.
Contact Detail:
References
Gleicher N, Liu
HC, Dudkiewicz A, Rosenwaks Z, Kaberlein G, Pratt D, Karande V.
Autoantibody profiles and immunoglobulin levels as predictors of in vitro
Fertilization success. Am J Obstet Gynecol 1994;179:1145-49.
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